“You have to assume that the hardware and underlying services are ephemeral, unreliable and may be broken or unavailable at any point, and that the other tenants in the multi-tenant public cloud will add random congestion and variance. In reality you always had this problem at scale, even with the most reliable hardware, so cloud ready architecture is about taking the patterns you have to use at large scale, and using them at a smaller scale to leverage the lowest cost infrastructure.”
via Netflix’s Advice on Moving to Amazon Web Services – ReadWriteCloud.